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- Postdoctoral Superstar Paul Sheppard
Our postdoc Paul is on a roll: giving talks, presenting posters, wining awards, and even publishing a paper! Join us in celebrating his recent adventures and accomplishments! First, on May 16th, Paul participated in the “120-Second Research Sprint” at Western Postdoctoral research Forum hosted by the Postdoctoral Association. If you want to know, in 120s, […]
2024 -
- When the conference doors close, these scientists rock out
“It’s a Monday night in mid-November, and a posse of 10 neuroscientists has taken the stage in a dive bar tucked into Washington, D.C.’s wharf region. The crowd consists of many fellow neuroscientists, some still wearing the dress shirts and loafers they donned earlier in the day to attend the annual meeting of the Society […]
2023 -
- TCNLab MD/PhD Student Shahnaza Hamidullah, and Recent Vanier Recipient in the News!
“To go from a girl who couldn’t speak English to getting an MD/PhD and a Vanier scholarship, I feel like I’m living a dream,” she said with emotion. “I feel so incredibly privileged to have had this chance given to me by my parents, by Canada, really everyone involved in getting me here.” Let’s shout […]
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- Metabolic hormones mediate cognition
Abstract Recent biochemical and behavioural evidence indicates that metabolic hormones not only regulate energy intake and nutrient content, but also modulate plasticity and cognition in the central nervous system. Disruptions in metabolic hormone signalling may provide a link between metabolic syndromes like obesity and diabetes, and cognitive impairment. For example, altered metabolic homeostasis in obesity […]
2022 -
- Decision Making in Mice During an Optimized Touchscreen Spatial Working Memory Task Sensitive to Medial Prefrontal Cortex Inactivation and NMDA Receptor Hypofunction
Abstract Working memory is a fundamental cognitive process for decision-making and is a hallmark impairment in a variety of neuropsychiatric and neurodegenerative diseases. Spatial working memory paradigms are a valuable tool to assess these processes in rodents and dissect the neurobiology underlying working memory. The trial unique non-match to location (TUNL) task is an automated […]
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- Perspectives on Cognitive Phenotypes and Models of Vascular Disease
New publication by lab PI Tim Bussey and fellow collaborators! Abstract: Clinical investigations have established that vascular-associated medical conditions are significant risk factors for various kinds of dementia. And yet, we are unable to associate certain types of vascular deficiencies with specific cognitive impairments. The reasons for this are many, not the least of which […]
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- The spontaneous location recognition task for assessing spatial pattern separation and memory across a delay in rats and mice
New TCNLab publication is out! Abstract Keeping similar memories distinct from one another is a critical cognitive process without which we would have difficulty functioning in everyday life. Memories are thought to be kept distinct through the computational mechanism of pattern separation, which reduces overlap between similar input patterns to amplify differences among stored representations. […]
2021 -
- Using touchscreen-delivered cognitive assessments to address the principles of the 3Rs in behavioral sciences
Abstract Despite considerable advances in both in silico and in vitro approaches, in vivo studies that involve animal model systems remain necessary in many research disciplines. Neuroscience is one such area, with studies often requiring access to a complete nervous system capable of dynamically selecting between and then executing a full range of cognitive and […]
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- Touchscreen Cognitive testing: Cross-Species Translation and Co-Clinical Trials in Neurodegenerative and Neuropsychiatric Disease
Abstract Translating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are central contributors to this challenge. Computer-automated cognitive test batteries […]
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- Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse PFC and hippocampus following obesogenic diet consumption
Abstract Emergent evidence demonstrates that excessive consumption of high fat and high sugar (HFHS) diets has negative consequences on hippocampal and prefrontal cortex (PFC) function. Moreover, the delayed maturation of the PFC including the late development of parvalbumin-expressing (PV) interneurons and perineuronal nets (PNNs) may promote vulnerability to HFHS diet-induced nutritional stress. However, the young […]
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- New Frontiers in Translational Research: Touchscreens, Open Science, and the Mouse Translational Research Accelerator Platform (MouseTRAP)
Abstract Many neurodegenerative and neuropsychiatric diseases and other brain disorders are accompanied by impairments in high‐level cognitive functions including memory, attention, motivation, and decision‐making. Despite several decades of extensive research, neuroscience is little closer to discovering new treatments. Key impediments include the absence of validated and robust cognitive assessment tools for facilitating translation from animal […]
2020 -
2019Beraldo, F.H., Palmer, D., Memar, S., Wasserman, D.I., Lee, WJ.V., Liang, S., Creighton, S.D., Kolisnyk, B., Cowan, M.F., Mels, J., Masood, T.S., CFodor, C., Al-Onaizi, M.C., Bartha, R., Gee, T., Saksida, L.M., Bussey, T.J., Strother, S.S., Prado, V.F., Winters, B.D., Prado, M.A.M.
2019 - MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment.
Authors: Flavio H Beraldo, Daniel Palmer, Sara Memar, David I Wasserman, Wai-Jane V Lee, Shuai Liang, Samantha D Creighton, Benjamin Kolisnyk, Matthew F Cowan, Justin Mels, Talal S Masood, Chris Fodor, Mohammed A Al-Onaizi, Robert Bartha, Tom Gee, Lisa M Saksida, Timothy J Bussey, Stephen S Strother, Vania F Prado, Boyer D Winters Is a […]
2019
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